- DNA extraction using differents kits depending the project .
- Quality control and quantity of samples:
- DNA quantification using Fluorometric methods
- Quality control using spectroscopy, TapeStation.
Genome-wide methylation analysis by microarray
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Sodium bisulfite DNA conversion and Verification of bisulfite treatment.
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Measurement of DNA methylation levels using Infinium HD chemistry (EPIC and Mouse) (Illumina iScan platform).
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Quality control of raw data using Genome Studio and minfi package.
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Normalization of methylation data.
- Epigenome-wide association studies (EWAS).
High-throughput sequencing
(genome and methylation)
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High-throughput sequencing of the clinical exome
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Whole-exome high-throughput sequencing
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High-throughput sequencing of custom gene panels
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Methylation analysis using RRBS method
High-throughput genotyping by microarray
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GWAS using Infinium HD chemistry (Illumina) (custom array design)
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Bioinformatics quality control of raw data using Genome Studio